Sardomozide dihydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I009291
  • CAS Number: 138794-73-7
  • Molecular Formula: C11H16Cl2N6
  • Molecular Weight: 303.19
  • Purity: ≥95%
Inquiry Now

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].


Catalog Number I009291
CAS Number 138794-73-7
Synonyms

(1E)-1-(diaminomethylidenehydrazinylidene)-2,3-dihydroindene-4-carboximidamide;dihydrochloride

Molecular Formula C11H16Cl2N6
Purity ≥95%
InChI InChI=1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15;;/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17);2*1H/b16-9+;;
InChIKey UHEIPGJSFDAPIC-NENXIMLWSA-N
SMILES C1CC(=NN=C(N)N)C2=C1C(=CC=C2)C(=N)N.Cl.Cl
Reference

[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7.
 [Content Brief]

[2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.
 [Content Brief]

Request a Quote