Sarecycline HCl

• CAT Number: I009292
• CAS Number: 1035979-44-2
• Molecular Formula: C24H30ClN3O8
• Molecular Weight: 523.97
• Purity: 95%
• Synonyms: P005672; P005672 HCl; Sarecycline hydrochloride;(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
• Target: Cell Cycle/DNA Damage
• Target Protein: P08183
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: M0.5 µg/ml
• IUPAC Name: (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
• InChI: InChI=1S/C24H29N3O8.ClH/c1-26(2)18-13-8-11-7-12-10(9-27(3)35-4)5-6-14(28)16(12)19(29)15(11)21(31)24(13,34)22(32)17(20(18)30)23(25)33;/h5-6,11,13,18,28-29,32,34H,7-9H2,1-4H3,(H2,25,33);1H/t11-,13-,18-,24-;/m0./s1
• InChIKey: JGPBDCKZLBSHOI-FIPJBXKNSA-N
• SMILES: CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)CN(C)OC.Cl

Sarecycline HCl（Cat No.:I009292）is a narrow-spectrum oral tetracycline-class antibiotic primarily used to treat moderate to severe acne vulgaris. By selectively inhibiting bacterial protein synthesis, it targets acne-causing bacteria, including Cutibacterium acnes, while minimizing the impact on gut microbiota compared to broader-spectrum tetracyclines. Sarecycline’s anti-inflammatory properties also help reduce inflammation associated with acne. Its favorable safety profile, with fewer gastrointestinal side effects, and reduced potential for antibiotic resistance make it an effective and well-tolerated option for long-term acne management.