For research use only. Not for therapeutic Use.
Saredutant, aslo known as SR-48968, is a NK2 receptor antagonist for the treatment of major depressive disorder. Saredutant has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant, ameliorates stress-induced conditions without impairing cognition. SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex. SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
| Catalog Number | M099542 |
| CAS Number | 142001-63-6 |
| Molecular Formula | C31H35Cl2N3O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide |
| InChI | InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1 |
| InChIKey | PGKXDIMONUAMFR-AREMUKBSSA-N |
| SMILES | CC(=O)NC1(CCN(CC1)CCC(CN(C)C(=O)C2=CC=CC=C2)C3=CC(=C(C=C3)Cl)Cl)C4=CC=CC=C4 |
| Reference | </br>1:Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant. Tamburella A, Leggio GM, Micale V, Navarria A, Bucolo C, Cicirata V, Drago F, Salomone S.Int J Neuropsychopharmacol. 2013 May;16(4):813-23. doi: 10.1017/S1461145712000612. Epub 2012 Jun 14. PMID: 22695046 </br>2:The neurokinin NK2 antagonist, saredutant, ameliorates stress-induced conditions without impairing cognition. Rogacki N, Lopez-Grancha M, Naimoli V, Potestio L, Stevens RJ, Pichat P, Bergis OE, Cohen C, Varty GB, Griebel G.Pharmacol Biochem Behav. 2011 May;98(3):405-11. doi: 10.1016/j.pbb.2010.11.017. Epub 2010 Nov 27. PMID: 21115031 </br>3:ACS chemical neuroscience molecule spotlight on Saredutant. Hopkins CR.ACS Chem Neurosci. 2010 Oct 20;1(10):653-4. doi: 10.1021/cn100061r. Review. PMID: 22776916 Free PMC Article</br>4:Effects of intra-hippocampal injections of the NK2 receptor antagonist saredutant on the elevated plus maze, and the mouse defense test battery. Borelli KG, Defensor EB, Blanchard DC, Blanchard RJ, Griebel G.Neurosci Lett. 2010 Nov 26;485(3):241-5. doi: 10.1016/j.neulet.2010.09.021. Epub 2010 Sep 19. PMID: 20849917 </br>5:Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Overstreet DH, Naimoli VM, Griebel G.Pharmacol Biochem Behav. 2010 Aug;96(2):206-10. doi: 10.1016/j.pbb.2010.05.006. Epub 2010 May 12. PMID: 20470817 </br>6:Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions. Micale V, Tamburella A, Leggio GM, Mazzola C, Li Volsi V, Drago F.Pharmacol Biochem Behav. 2008 Sep;90(3):463-9. doi: 10.1016/j.pbb.2008.04.003. Epub 2008 Apr 12. PMID: 18495229 </br>7:Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models. Louis C, Stemmelin J, Boulay D, Bergis O, Cohen C, Griebel G.Pharmacol Biochem Behav. 2008 Mar;89(1):36-45. Epub 2007 Nov 5. PMID: 18045668 </br>8:The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics. Van Schoor J, Joos GF, Chasson BL, Brouard RJ, Pauwels RA.Eur Respir J. 1998 Jul;12(1):17-23. PMID: 9701408 Free Article |
