Saridegib

• CAT Number: I009210
• CAS Number: 1037210-93-7
• Molecular Formula: C29H48N2O3S
• Molecular Weight: 504.77
• Purity: ≥95%
• Synonyms: IPI-926, Patidegib, IPI 926
• Target: Smo
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide
• InChI: InChI=1S/C29H48N2O3S/c1-17-12-26-27(30-16-17)19(3)29(34-26)11-9-22-23-7-6-20-13-21(31-35(5,32)33)8-10-28(20,4)25(23)14-24(22)18(2)15-29/h17,19-23,25-27,30-31H,6-16H2,1-5H3/t17-,19+,20+,21+,22-,23-,25-,26+,27-,28-,29-/m0/s1
• InChIKey: HZLFFNCLTRVYJG-WWGOJCOQSA-N
• SMILES: C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC[C@@H]6C[C@@H](CC[C@@]6([C@H]5CC4=C(C3)C)C)NS(=O)(=O)C)C)NC1

Saridegib(CAT: I009210) is a potent Hedgehog pathway inhibitor that targets and suppresses the activity of Smoothened (SMO), a key transmembrane protein in the Hedgehog signaling cascade. By blocking SMO, Saridegib disrupts downstream signaling crucial for tumor growth and survival, effectively inhibiting cancer cell proliferation. This mechanism makes it particularly valuable in oncology research, especially for studying basal cell carcinoma and other Hedgehog pathway-dependent cancers. Saridegib’s precise mode of action offers researchers a robust tool for exploring targeted cancer therapies, advancing drug discovery, and developing novel treatments for malignancies driven by aberrant Hedgehog signaling.