For research use only. Not for therapeutic Use.
Sarolaner（Cat No.:I009294）is an isoxazoline-class antiparasitic agent used in veterinary medicine to control ectoparasites such as fleas and ticks in dogs and cats. It works by inhibiting the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system of parasites, leading to hyperexcitation, paralysis, and death. Sarolaner is highly effective with rapid onset and sustained activity, providing month-long protection against multiple ectoparasite species. Its safety and efficacy profile make it a trusted choice for preventing infestations and protecting companion animals from vector-borne diseases.
| Catalog Number | I009294 |
| CAS Number | 1398609-39-6 |
| Synonyms | PF-6450567; PF 6450567; PF6450567; Sarolaner;(S)-1-(5/’-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3/’H-spiro[azetidine-3,1/’-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one |
| Molecular Formula | C23H18Cl2F4N2O5S |
| Purity | ≥95% |
| Target | Parasite |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone |
| InChI | InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1 |
| InChIKey | FLEFKKUZMDEUIP-QFIPXVFZSA-N |
| SMILES | CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F |
| Reference | <br /> |
