Sarolaner

• CAT Number: I009294
• CAS Number: 1398609-39-6
• Molecular Formula: C23H18Cl2F4N2O5S
• Molecular Weight: 581.36
• Purity: ≥95%
• Synonyms: PF-6450567; PF 6450567; PF6450567; Sarolaner;(S)-1-(5/’-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3/’H-spiro[azetidine-3,1/’-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethan-1-one
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
• InChI: InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1
• InChIKey: FLEFKKUZMDEUIP-QFIPXVFZSA-N
• SMILES: CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F

Sarolaner（Cat No.:I009294）is an isoxazoline-class antiparasitic agent used in veterinary medicine to control ectoparasites such as fleas and ticks in dogs and cats. It works by inhibiting the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system of parasites, leading to hyperexcitation, paralysis, and death. Sarolaner is highly effective with rapid onset and sustained activity, providing month-long protection against multiple ectoparasite species. Its safety and efficacy profile make it a trusted choice for preventing infestations and protecting companion animals from vector-borne diseases.

Reference

1:Speed of kill of a new spot-on formulation of selamectin plus sarolaner for cats against induced infestations with Ixodes ricinus. Becskei C, Lin D, Rugg D, Geurden T.Vet Parasitol. 2017 Apr;238 Suppl 1:S8-S11. doi: 10.1016/j.vetpar.2017.03.009. PMID: 28395756 Free Article
2:Efficacy of a new spot-on formulation of selamectin plus sarolaner against Ancylostoma tubaeforme and Toxocara cati in cats. Geurden T, Vatta AF, Slootmans N, King VL, Lin D, McTier T, Rugg D.Vet Parasitol. 2017 Apr;238 Suppl 1:S31-S35. doi: 10.1016/j.vetpar.2017.02.027. PMID: 28395755 Free Article
3:Efficacy of a new spot-on formulation of selamectin plus sarolaner against four common tick species infesting cats in Europe. Geurden T, Becskei C, Vatta AF, Slootmans N, von Reitzenstein M, King VL, Lin D, Rugg D.Vet Parasitol. 2017 Apr;238 Suppl 1:S3-S7. doi: 10.1016/j.vetpar.2017.02.028. PMID: 28395754 Free Article
4:Efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment of Otodectes cynotis in cats. Becskei C, Reinemeyer C, King VL, Lin D, Myers MR, Vatta AF.Vet Parasitol. 2017 Apr;238 Suppl 1:S27-S30. doi: 10.1016/j.vetpar.2017.02.029. PMID: 28395753 Free Article
5:Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats against adult Ctenocephalides felis, flea egg production and adult flea emergence. Vatta AF, Everett WR, Holzmer SJ, Cherni JA, King VL, Rugg D, Geurden T.Vet Parasitol. 2017 Apr;238 Suppl 1:S22-S26. doi: 10.1016/j.vetpar.2017.02.026. PMID: 28395752 Free Article
6:Efficacy and speed of kill of a new spot-on formulation of selamectin plus sarolaner against flea infestations in cats. Becskei C, Cherni JA, Vatta AF, King VL, Lin D, Rugg D.Vet Parasitol. 2017 Apr;238 Suppl 1:S18-S21. doi: 10.1016/j.vetpar.2017.03.010. PMID: 28395751 Free Article
7:Efficacy and safety of a new spot-on formulation of selamectin plus sarolaner in the treatment of naturally occurring flea and tick infestations in cats presented as veterinary patients in Europe. Geurden T, Becskei C, Farkas R, Lin D, Rugg D.Vet Parasitol. 2017 Apr;238 Suppl 1:S12-S17. doi: 10.1016/j.vetpar.2017.03.008. PMID: 28395750 Free Article
8:Tradition and innovation: selamectin plus sarolaner. A new tool to control endo- and ectoparasites of cats – a European perspective. Otranto D, Little S.Vet Parasitol. 2017 Apr;238 Suppl 1:S1-S2. doi: 10.1016/j.vetpar.2017.03.006. No abstract available. PMID: 28395749 Free Article
9:The conclusion of a comparative efficacy study of fluralaner and sarolaner against the tick Amblyomma americanum on dogs is based on results obtained at study times that are outside the fluralaner label recommendations. Armstrong R.Parasit Vectors. 2017 Mar 24;10(1):159. doi: 10.1186/s13071-017-2100-1. PMID: 28340604 Free PMC Article
10:Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ixodes holocyclus on dogs. Packianathan R, Hodge A, Bruellke N, Davis K, Maeder S.Parasit Vectors. 2017 Feb 21;10(1):98. doi: 10.1186/s13071-017-2024-9. PMID: 28222813 Free PMC Article