SARS-CoV-2-IN-13

• CAT Number: I043707
• CAS Number: 56961-10-5
• Molecular Formula: C13H8Cl2N2O4
• Molecular Weight: 327.12
• Purity: ≥95%
• Synonyms: 5-chloro-N-(3-chloro-4-nitrophenyl)-2-hydroxybenzamide
• InChI: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-8-2-3-11(17(20)21)10(15)6-8/h1-6,18H,(H,16,19)
• InChIKey: FKLGWJUBUPDJJI-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1NC(=O)C2=C(C=CC(=C2)Cl)O)Cl)[N+](=O)[O-]

SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Reference

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.
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