SARS-CoV-2-IN-14

• CAT Number: I043706
• CAS Number: 22203-98-1
• Molecular Formula: C13H9Cl2NO2
• Molecular Weight: 282.12
• Purity: ≥95%
• Synonyms: 5-chloro-N-(3-chlorophenyl)-2-hydroxybenzamide
• InChI: InChI=1S/C13H9Cl2NO2/c14-8-2-1-3-10(6-8)16-13(18)11-7-9(15)4-5-12(11)17/h1-7,17H,(H,16,18)
• InChIKey: NXDGLRGDIKDWIF-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

SARS-CoV-2-IN-14 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.39 μM. SARS-CoV-2-IN-14 is a niclosamide analogue. SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Reference

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.
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