SARS-CoV-2-IN-39

• CAT Number: I040937
• CAS Number: 2882823-03-0
• Molecular Formula: C14H8ClF4NO3
• Molecular Weight: 349.66
• Purity: ≥95%
• Synonyms: 5-chloro-4-fluoro-2-hydroxy-N-[4-(trifluoromethoxy)phenyl]benzamide
• InChI: InChI=1S/C14H8ClF4NO3/c15-10-5-9(12(21)6-11(10)16)13(22)20-7-1-3-8(4-2-7)23-14(17,18)19/h1-6,21H,(H,20,22)
• InChIKey: AGOOHZQXJABZCD-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC(=O)C2=CC(=C(C=C2O)F)Cl)OC(F)(F)F

SARS-CoV-2-IN-39 (compound 21) is a SARS-CoV-2 inhibitor with an EC50 of 1 μM. SARS-CoV-2-IN-39 against SARS-CoV-2 by inhibiting of SKP2 protein and stabilizing BECN1[1].

Reference

[1]. Rui Li, et al. Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2. Eur J Med Chem. 2023 May 5;253:115320.
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