Saxagliptin hydrate

• CAT Number: A000017
• CAS Number: 945667-22-1
• Molecular Formula: C18H25N3O2.H2O
• Molecular Weight: 333.43
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C1C2CC2N(C1C#N)C(=O)C(C34CC5CC(C3)CC(C5)(C4)O)N.O

Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

Reference

[1] Neumiller JJ, et al. Am J Health Syst Pharm. 2010, 67(18):1515-25.
[2] Solini A, et al. Vascul Pharmacol. 2016, 76:62-71.
[3] Henry RR, et al. Diabetes Obes Metab. 2011, 13(9):850-8.
[4] Sbaraglini ML, et al. Eur J Pharmacol. 2014, 727:8-14.