Sazetidine-A dihydrochloride

• CAT Number: I012242
• CAS Number: 820231-95-6
• Molecular Formula: C15H22Cl2N2O2
• Molecular Weight: 6-[5-[[(2S)-azetidin-2-yl]methoxy]pyridin-3-yl]hex-5-yn-1-ol
• Purity: ≥95%
• Synonyms: 6-(5-(((S)-azetidin-2-yl)methoxy)pyridin-3-yl)hex-5-yn-l-ol dihydrochloride; saz-A
• InChI: InChI=1S/C15H20N2O2/c18-8-4-2-1-3-5-13-9-15(11-16-10-13)19-12-14-6-7-17-14/h9-11,14,17-18H,1-2,4,6-8,12H2/t14-/m0/s1
• InChIKey: WONBUILDJNKYCB-AWEZNQCLSA-N
• SMILES: C1CN[C@@H]1COC2=CN=CC(=C2)C#CCCCCO

Sazetidine-A dihydrochloride(CAT: I012242) is a selective partial agonist and desensitizing agent of α4β2 nicotinic acetylcholine receptors (nAChRs). By selectively desensitizing high-affinity nAChRs while sparing other subtypes, Sazetidine-A modulates cholinergic neurotransmission, making it a valuable tool in neuropharmacology research. It has shown potential in preclinical studies for addressing conditions such as addiction, depression, and cognitive disorders. Sazetidine-A’s unique mechanism provides insights into the role of α4β2 nAChRs in central nervous system function and offers a promising pathway for developing therapeutic strategies for neuropsychiatric and neurodegenerative diseases.