For research use only. Not for therapeutic Use.
SB 221284（Cat No.:I009317）is a selective small molecule inhibitor that targets the protein kinase 1 (PIKfyve), an enzyme involved in cellular processes such as endocytosis and vesicle trafficking. By inhibiting PIKfyve, SB 221284 modulates membrane dynamics and has shown potential in regulating cellular signaling pathways, including those linked to cancer and neurodegenerative diseases. Research suggests that it may have therapeutic applications in treating conditions where these processes are dysregulated, such as in certain cancers or viral infections. SB 221284 is still under investigation in preclinical studies to evaluate its efficacy and safety profile.
| Catalog Number | I009317 |
| CAS Number | 196965-14-7 |
| Synonyms | SB 221284; SB221284; SB-221284.;5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
| Molecular Formula | C16H14F3N3OS |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Store at 4 °C |
| IUPAC Name | 5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
| InChI | InChI=1S/C16H14F3N3OS/c1-24-14-7-10-4-6-22(13(10)8-12(14)16(17,18)19)15(23)21-11-3-2-5-20-9-11/h2-3,5,7-9H,4,6H2,1H3,(H,21,23) |
| InChIKey | OQZOXHCRSXYSPM-UHFFFAOYSA-N |
| SMILES | CSC1=C(C=C2C(=C1)CCN2C(=O)NC3=CN=CC=C3)C(F)(F)F |
| Reference | </br>1:Takeuchi K, Mohammad S, Ozaki T, Morioka E, Kawaguchi K, Kim J, Jeong B, Hong JH, Lee KJ, Ikeda M. Serotonin-2C receptor involved serotonin-induced Ca²⁺ mobilisations in neuronal progenitors and neurons in rat suprachiasmatic nucleus. Sci Rep. 2014 Feb 17;4:4106. doi: 10.1038/srep04106. PubMed PMID: 24531181; PubMed Central PMCID: PMC3925950.</br>2:Murray F, Hutson PH. Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. Eur J Pharmacol. 2007 Aug 13;569(1-2):41-7. Epub 2007 May 13. PubMed PMID: 17582397. |
