SB 242084 hydrochloride

• CAT Number: I000275
• CAS Number: 1049747-87-6
• Molecular Formula: C21H19ClN4O2 • 2HCl
• Molecular Weight: 467.81
• Purity: ≥95%
• Synonyms: 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide, dihydrochloride
• Target: Neuronal Signaling
• Solubility: 50 mM in water (water soluble)
• Storage: -20°C
• IC50: 9.0(pKi) [1]
• IUPAC Name: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride
• InChI: InChI=1S/C21H19ClN4O2.2ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);2*1H
• InChIKey: GCMNSEILNIPNSX-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CN=C(C=C3)OC4=C(N=CC=C4)C.Cl.Cl

SB 242084 hydrochloride(CAT: I000275) is a highly selective and potent 5-HT₂C receptor antagonist with a pKi of 9.0. It exhibits 158-fold selectivity over the 5-HT₂A receptor and 100-fold selectivity over the 5-HT₂B receptor, ensuring targeted inhibition of 5-HT₂C-mediated signaling. The 5-HT₂C receptor plays a critical role in regulating mood, anxiety, appetite, and cognitive function. SB 242084 is widely used in neuropharmacology research to study the serotonergic system and has potential therapeutic applications in treating anxiety disorders, depression, schizophrenia, and obesity due to its ability to modulate mood and feeding behavior.