For research use only. Not for therapeutic Use.
Selective and brain penetrant 5-HT2C receptor antagonist. The freebase SB 242084 is available as Axon 4092.
Keywords: SB 242084 hydrochloride | Supplier | 181632-25-7 | 1260505-34-7 | 5-HT2C antagonist | SB242084 | 5-HT2C
| Catalog Number | I047562 |
| CAS Number | 1260505-34-7 |
| Molecular Formula | C21H19ClN4O2.HCl |
| Purity | ≥95% |
| IUPAC Name | 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;hydrochloride |
| InChI | InChI=1S/C21H19ClN4O2.ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);1H |
| SMILES | CC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CN=C(C=C3)OC4=C(N=CC=C4)C.Cl |
| Reference | SM Bromidge et al. 6-Chloro-5-methyl-1-[[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. J. Med. Chem. 1997, 40(22), 3494-3496.
GA Kennet et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 1997, 36(4-5), 609-620.
GL Dalton et al. Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. Psychopharmacol. 2006, 185(1), 45-57. |
