For research use only. Not for therapeutic Use.
SB 242235（Cat No.:I002479）is a potent and selective inhibitor of p38 MAPK, particularly the p38α isoform, which plays a key role in the regulation of inflammation and stress responses. By inhibiting p38 MAPK, SB 242235 reduces the production of pro-inflammatory cytokines and has been explored for its therapeutic potential in treating inflammatory diseases such as rheumatoid arthritis and other autoimmune conditions. It is also used in research to study the role of p38 MAPK in cell signaling pathways related to inflammation, apoptosis, and various stress-induced cellular processes.
| Catalog Number | I002479 |
| CAS Number | 193746-75-7 |
| Synonyms | 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine |
| Molecular Formula | C19H20FN5O |
| Purity | ≥95% |
| Target | p38 MAPK; Autophagy |
| Solubility | DMSO: ≥ 48 mg/mL |
| Storage | Store at -20C |
| IC50 | 1.0 uM |
| IUPAC Name | 4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]-2-methoxypyrimidine |
| InChI | InChI=1S/C19H20FN5O/c1-26-19-22-11-8-16(24-19)18-17(13-2-4-14(20)5-3-13)23-12-25(18)15-6-9-21-10-7-15/h2-5,8,11-12,15,21H,6-7,9-10H2,1H3 |
| InChIKey | PDTYLGXVBIWRIM-UHFFFAOYSA-N |
| SMILES | COC1=NC=CC(=N1)C2=C(N=CN2C3CCNCC3)C4=CC=C(C=C4)F |
| Reference | </br>1:SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man. Ward KW, Proksch JW, Gorycki PD, Yu CP, Ho MY, Bush BD, Levy MA, Smith BR.Xenobiotica. 2002 Mar;32(3):235-50. PMID: 11958562 </br>2:SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics. Ward KW, Proksch JW, Salyers KL, Azzarano LM, Morgan JA, Roethke TJ, McSurdy-Freed JE, Levy MA, Smith BR.Xenobiotica. 2002 Mar;32(3):221-33. PMID: 11958561 </br>3:Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures. Badger AM, Roshak AK, Cook MN, Newman-Tarr TM, Swift BA, Carlson K, Connor JR, Lee JC, Gowen M, Lark MW, Kumar S.Osteoarthritis Cartilage. 2000 Nov;8(6):434-43. PMID: 11069728 Free Article</br>4:Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Badger AM, Griswold DE, Kapadia R, Blake S, Swift BA, Hoffman SJ, Stroup GB, Webb E, Rieman DJ, Gowen M, Boehm JC, Adams JL, Lee JC.Arthritis Rheum. 2000 Jan;43(1):175-83. PMID: 10643714 Free Article |
