SB 272183

• CAT Number: I009329
• CAS Number: 216058-27-4
• Molecular Formula: C29H28ClN5O
• Molecular Weight: 498.03
• Purity: ≥95%
• Synonyms: SB 272183; SB272183; SB-272183.;5-chloro-6-(4-methylpiperazin-1-yl)-N-(4-pyridin-4-ylnaphthalen-1-yl)-2,3-dihydroindole-1-carboxamide
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 5-chloro-6-(4-methylpiperazin-1-yl)-N-(4-pyridin-4-ylnaphthalen-1-yl)-2,3-dihydroindole-1-carboxamide
• InChI: InChI=1S/C29H28ClN5O/c1-33-14-16-34(17-15-33)28-19-27-21(18-25(28)30)10-13-35(27)29(36)32-26-7-6-22(20-8-11-31-12-9-20)23-4-2-3-5-24(23)26/h2-9,11-12,18-19H,10,13-17H2,1H3,(H,32,36)
• InChIKey: DAPBIPAGJXKFCI-UHFFFAOYSA-N
• SMILES: O=C(N1CCC2=C1C=C(N3CCN(C)CC3)C(Cl)=C2)NC4=C5C=CC=CC5=C(C6=CC=NC=C6)C=C4

SB 272183(CAT: I009329) is a highly potent dual antagonist of the 5-HT1A and 5-HT1B serotonin receptors, designed as a potential antidepressant. By blocking these receptors, it modulates serotonergic neurotransmission, enhancing serotonin availability in key brain regions associated with mood regulation. This dual mechanism positions SB 272183 as a valuable compound in neuroscience research, particularly in the study of depression, anxiety, and other mood disorders. Its receptor specificity and potency provide researchers with a powerful tool for exploring novel therapeutic strategies targeting serotonergic pathways in mental health conditions.