SB-273005

• CAT Number: I011639
• CAS Number: 205678-31-5
• Molecular Formula: C22H24F3N3O4
• Molecular Weight: 451.44
• Purity: ≥95%
• Synonyms: 2-[(4S)-8-[2-[6-(methylamino)pyridin-2-yl]ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]acetic acid
• InChI: InChI=1S/C22H24F3N3O4/c1-26-19-4-2-3-17(27-19)7-8-32-18-6-5-14-9-15(11-20(29)30)21(31)28(12-16(14)10-18)13-22(23,24)25/h2-6,10,15H,7-9,11-13H2,1H3,(H,26,27)(H,29,30)/t15-/m0/s1
• InChIKey: KSSPHFGIOASRDE-HNNXBMFYSA-N
• SMILES: CNC1=CC=CC(=N1)CCOC2=CC3=C(C[C@H](C(=O)N(C3)CC(F)(F)F)CC(=O)O)C=C2

SB-273005（Cat No.:I011639）is a selective inhibitor of the Rho-associated protein kinase 2 (ROCK2), an enzyme involved in regulating actin cytoskeleton dynamics, cell motility, and various cellular processes such as cell proliferation and survival. ROCK2 plays a significant role in pathological conditions like cancer metastasis, fibrosis, and cardiovascular diseases. By inhibiting ROCK2, SB-273005 aims to reduce abnormal cell migration and invasion, offering potential therapeutic benefits in diseases characterized by excessive cell movement and tissue remodeling. This compound is being studied for its potential in treating cancer, fibrosis, and other related conditions.