SB-277011

• CAT Number: I002653
• CAS Number: 215803-78-4
• Molecular Formula: C28H30N4O
• Molecular Weight: 438.56
• Purity: ≥95%
• Synonyms: N-(4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide
• Target: Dopamine Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 8.0 (pKi)

SB-277011 (Cat.No:I002653) is a selective dopamine D3 receptor antagonist. It has been studied for its potential in the treatment of substance abuse disorders, particularly drug addiction. SB-277011 works by modulating the dopamine reward system, reducing drug-seeking behavior, and may offer therapeutic benefits in addiction management. Clinical research is ongoing to explore its efficacy and safety.

Reference

[1]. Higley, Amanda E.; Kiefer, Stephen W.; Li, Xia; Gaal, Jozsef; Xi, Zheng-Xiong; Gardner, Eliot L. Dopamine D3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. European journal of pharmacology (2011), 659(2-3), 187-192.
[2]. Clément P, Pozzato C, Heidbreder C, Alexandre L, Giuliano F, Melotto S.Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat.J Sex Med. 2009 Apr;6(4):980-8. Epub 2008 Feb 4.
[3]. Gyertyán I, Sághy K.The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats.Eur J Pharmacol. 2007 Oct 31;572(2-3):171-4. Epub 2007 Jun 29.
[4]. Southam E, Lloyd A, Jennings CA, Cluderay JE, Cilia J, Gartlon JE, Jones DN.Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain.Brain Res. 2007 May 29;1149:50-7. Epub 2007 Feb 28.
[5]. Pak AC, Ashby CR Jr, Heidbreder CA, Pilla M, Gilbert J, Xi ZX, Gardner EL.The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.Int J Neuropsychopharmacol. 2006 Oct;9(5):585-602. Epub 2006 Aug 31.