For research use only. Not for therapeutic Use.
Potent, selective and brain penetrating D3 dopamine receptor antagonist; with high affinity for the hD3 receptor (pKi = 7.95) and 100-fold selectivity over the hD2 receptor and over 66 other receptors.
KEYWORDS: SB 277011A | supplier | D3 antagonist | SB 277011 dihydrochloride | SB277011A | SB277011 | CAS [1226917-67-4] | [215803-78-4] | Dopamine | GPCR | drug addiction
| Catalog Number | I010911 |
| CAS Number | 1226917-67-4 |
| Molecular Formula | C28H30N4O.2HCl |
| Purity | ≥95% |
| IUPAC Name | N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide;dihydrochloride |
| InChI | InChI=1S/C28H30N4O.2ClH/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);2*1H |
| SMILES | C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45.Cl.Cl |
| Reference | G Stemp et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist (…). J. Med. Chem. 2000, 43(9), 1878-1885.
C Reavill et al. Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A. J. Pharmacol. Exp. Ther. 2000, 294(3), 1154-1165.
E Southam et al. Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain. Brain Res. 2007, 1149, 50-57. |
