SB-282241

• CAT Number: I009331
• CAS Number: 299173-56-1
• Molecular Formula: C27H31Cl2N3O2
• Molecular Weight: 500.46
• Purity: ≥95%
• Synonyms: SB-282241; SB 282241; SB282241; TCMDC-139245; TCMDC139245.;(E)-3-(3,4-dichlorophenyl)-N-[5-[4-(5-hydroxy-1H-indol-3-yl)piperidin-1-yl]pentyl]prop-2-enamide
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (E)-3-(3,4-dichlorophenyl)-N-[5-[4-(5-hydroxy-1H-indol-3-yl)piperidin-1-yl]pentyl]prop-2-enamide
• InChI: InChI=1S/C27H31Cl2N3O2/c28-24-7-4-19(16-25(24)29)5-9-27(34)30-12-2-1-3-13-32-14-10-20(11-15-32)23-18-31-26-8-6-21(33)17-22(23)26/h4-9,16-18,20,31,33H,1-3,10-15H2,(H,30,34)/b9-5+
• InChIKey: QBRLVMQBZIFWTB-WEVVVXLNSA-N
• SMILES: C1CN(CCC1C2=CNC3=C2C=C(C=C3)O)CCCCCNC(=O)/C=C/C4=CC(=C(C=C4)Cl)Cl

SB-282241（Cat No.:I009331）is a potent and selective inhibitor of the protein kinase Pim-1, a serine/threonine kinase involved in cell survival, proliferation, and differentiation. Pim-1 is often overexpressed in various cancers, including leukemia, lymphoma, and solid tumors, and its activity is associated with promoting tumorigenesis and resistance to chemotherapy. By inhibiting Pim-1, SB-282241 disrupts these processes, inducing apoptosis and sensitizing cancer cells to other treatments. It has shown promise in preclinical studies as an anti-cancer agent, particularly in combination with other therapies to overcome drug resistance and improve treatment outcomes.