SB 290157 (trifluoroacetate salt)

• CAT Number: I009332
• CAS Number: 1140525-25-2(SB 290157 trifluoroacetate salt), 259218-28-5 (SB 290157).
• Molecular Formula: C24H29F3N4O6
• Molecular Weight: 526.51
• Purity: ≥95%
• Synonyms: SB 290157 (trifluoroacetate salt); SB 290157; SB-290157; SB290157.;N2-[2-(2,2-diphenylethoxy)acetyl]-L-arginine, 2,2,2-trifluoroacetate
• Target: Complement System
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IC50: 200 nM
• InChI: InChI=1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1
• InChIKey: ZJRMPPVJAQWGEG-FYZYNONXSA-N
• SMILES: N=C(N)NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O.O=C(O)C(F)(F)F

SB 290157 (trifluoroacetate salt) (Cat No.: I009332) is a selective, non-peptide antagonist of the complement C3a receptor (C3aR). It inhibits C3a-mediated immune responses, including inflammation, cell migration, and cytokine release. SB 290157 is widely used in immunology research to study the complement system’s role in autoimmune diseases, allergic reactions, and inflammatory disorders. By blocking C3aR activation, it helps elucidate complement-driven pathologies and potential therapeutic interventions for conditions such as asthma, sepsis, and neuroinflammatory diseases.

Reference

1. Ames, R.S.,Li, Y.,Sarau, H.M., et al. Molecular cloning and characterization of the human anaphylatoxin C3a receptor. The Journal of Biological Chemisty 271(34), 20231-20234 (1996).2. Ames, R.S.,Lee, D.,Foley, J.J., et al. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. Journal of Immunology 166(10), 6341-6348 (2001).