SB-328437

• CAT Number: I009333
• CAS Number: 247580-43-4
• Molecular Formula: C21H18N2O5
• Molecular Weight: 378.38
• Purity: ≥95%
• Synonyms: methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
• InChI: InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• InChIKey: VMFGCGRAIBLAFY-IBGZPJMESA-N
• SMILES: COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32

SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM[1].

Reference

[1]. White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275(47):36626-31. 
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