SB-332235

• CAT Number: I009334
• CAS Number: 276702-15-9
• Molecular Formula: C13H10Cl3N3O4S
• Molecular Weight: 410.65
• Purity: ≥95%
• Synonyms: SB-332235; SB 332235; SB332235.;6-chloro-3-(3-(2,3-dichlorophenyl)ureido)-2-hydroxybenzenesulfonamide
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 1-(4-chloro-2-hydroxy-3-sulfamoylphenyl)-3-(2,3-dichlorophenyl)urea
• InChI: InChI=1S/C13H10Cl3N3O4S/c14-6-2-1-3-8(10(6)16)18-13(21)19-9-5-4-7(15)12(11(9)20)24(17,22)23/h1-5,20H,(H2,17,22,23)(H2,18,19,21)
• InChIKey: WTLRWOHEKQGKDS-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)Cl)Cl)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)N)O

SB-332235 (Cat No.: I009334) is a selective and potent inhibitor of p38 mitogen-activated protein kinase (MAPK), an enzyme involved in cellular responses to stress and inflammation. It has been used primarily in research to explore the role of p38 MAPK in inflammatory diseases, including arthritis and autoimmune disorders. By blocking this signaling pathway, SB-332235 helps reduce the production of pro-inflammatory cytokines. It serves as a valuable tool for understanding p38 MAPK function and holds potential for developing anti-inflammatory and immunomodulatory therapies.

Reference

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