For research use only. Not for therapeutic Use.
SB-366791（Cat No.:I003637）is a selective small molecule antagonist of the GPR40 (FFAR1) receptor, a G-protein-coupled receptor (GPCR) that plays a role in the regulation of insulin secretion and glucose metabolism. GPR40 is activated by long-chain fatty acids and is involved in mediating insulinotropic effects. SB-366791 has been studied for its potential to modulate insulin release and improve glycemic control, making it a candidate for treating type 2 diabetes. Research also suggests it may have applications in other metabolic disorders, though further clinical testing is required to evaluate its efficacy, safety, and therapeutic potential.
| CAS Number | 472981-92-3 |
| Synonyms | SB366791;SB 366791 |
| Molecular Formula | C16H14ClNO2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| Storage | Store at RT |
| IC50 | 5.7±1.2 nM |
| IUPAC Name | (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide |
| InChI | InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+ |
| InChIKey | RYAMDQKWNKKFHD-JXMROGBWSA-N |
| SMILES | COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl |
| Reference | </br>1:TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Lappin SC, Randall AD, Gunthorpe MJ, Morisset V.Eur J Pharmacol. 2006 Jul 1;540(1-3):73-81. Epub 2006 May 6. PMID: 16737693 </br>2:Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Luis Hannan S, Lappin SC, Egerton J, Smith GD, Worby A, Howett L, Owen D, Nasir S, Davies CH, Thompson M, Wyman PA, Randall AD, Davis JB.Neuropharmacology. 2004 Jan;46(1):133-49. Erratum in: Neuropharmacology. 2004 May;46(6):905. PMID: 14654105 |
