For research use only. Not for therapeutic Use.
SB 399885 hydrochloride (CAT: I010718) is a highly potent and orally active antagonist of the SR-6 receptor. It exhibits excellent brain penetration and has a high selectivity for SR-6 compared to other serotonin receptors. With pKi values of 9.11, 8.81, and 9.02 for human recombinant, native rat, and native human SR-6 receptors, respectively, SB 399885 hydrochloride demonstrates its specificity for SR-6. This compound has potential applications in research related to serotonin signaling, neuropharmacology, and the development of novel therapeutic interventions targeting the SR-6 receptor.
| Catalog Number | I010718 |
| CAS Number | 402713-81-9 |
| Synonyms | SB399885 HCl; SB399885; SB399885 Hydrochloride; SB 399885; SB-399885.;N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamidehydrochloride |
| Molecular Formula | C18H22Cl3N3O4S |
| Purity | ≥95% |
| Target | SR-6 antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| Related CAS | 402713-80-8(free base) |
| InChI | InChI=1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;/h3-4,9-11,21-22H,5-8H2,1-2H3;1H |
| InChIKey | RNKCEBCFUSXSQE-UHFFFAOYSA-N |
| SMILES | O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Cl)=CC(Cl)=C3OC)=O.[H]Cl |
| Reference | <br /> |
