For research use only. Not for therapeutic Use.
SB-3CT (Cat No.:I003017) is a selective inhibitor of matrix metalloproteinase (MMP) activity, particularly MMP-2 and MMP-9. It exhibits potential as an anti-metastatic agent by preventing the degradation of extracellular matrix components, such as collagen and gelatin. SB-3CT’s inhibition of MMPs holds promise for applications in cancer therapy and inflammatory disorders, where MMPs play a role in tumor invasion, metastasis, and tissue damage. By targeting specific MMPs, SB-3CT offers a valuable tool for studying their functions and developing therapeutic strategies to combat these pathological processes.
| Catalog Number | I003017 |
| CAS Number | 292605-14-2 |
| Synonyms | Matrix Metalloproteinase-2/9 Inhibitor IV;MMP-2/MMP-9 Inhibitor IV |
| Molecular Formula | C15H14O3S2 |
| Purity | ≥95% |
| Target | MMP2/MMP9 inhibitor |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| IC50 | 13.9 nM/600 nM (MMP2/MMP9) |
| IUPAC Name | 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane |
| InChI | InChI=1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2 |
| InChIKey | LSONWRHLFZYHIN-UHFFFAOYSA-N |
| SMILES | C1C(S1)CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=CC=C3 |
| Reference | </br>1:MMP-9 inhibitor SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Jia F, Yin YH, Gao GY, Wang Y, Cen L, Jiang JY.J Neurotrauma. 2014 Jul 1;31(13):1225-34. doi: 10.1089/neu.2013.3230. Epub 2014 Jun 3. PMID: 24661104 Free PMC Article</br>2:QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue. Zhou J, Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB.J Chem Theory Comput. 2010 Nov 9;6(11):3580-3587. PMID: 21076643 Free PMC Article</br>3:Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT. Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB.J Phys Chem B. 2010 Jan 21;114(2):1030-7. doi: 10.1021/jp909327y. PMID: 20039633 Free PMC Article</br>4:DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2. Tao P, Fisher JF, Mobashery S, Schlegel HB.Org Lett. 2009 Jun 18;11(12):2559-62. doi: 10.1021/ol9008393. PMID: 19445474 Free PMC Article |
