SB-408124

• CAT Number: I002988
• CAS Number: 288150-92-5
• Molecular Formula: C19H18F2N4O
• Molecular Weight: 356.37
• Purity: ≥95%
• Synonyms: 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea
• Target: Neuronal Signaling
• Solubility: DMSO 36 mg/mL; Water <1 mg/mL
• Storage: 3 years -20C powder
• IC50: 57 nM(Ki)
• InChI: InChI=1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)
• InChIKey: JTARFZSNUAGHRB-UHFFFAOYSA-N
• SMILES: CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C

SB-408124（Cat No.:I002988）is a selective antagonist of the histamine H4 receptor, a receptor involved in immune and inflammatory responses. By blocking H4 receptors, SB-408124 helps modulate the activity of immune cells, particularly mast cells and eosinophils, which are key players in allergic and inflammatory conditions. It has been studied in preclinical models for its potential to treat conditions such as asthma, allergic rhinitis, and other inflammatory diseases. SB-408124’s selective inhibition of the H4 receptor makes it a valuable tool for exploring novel therapeutic strategies in immune-related disorders.

Reference

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