For research use only. Not for therapeutic Use.
SB-429201 is a potent and selective HDAC1 (IC50~1.5 μM). SB-429201 displays at least a 20-fold preference for HDAC1 inhibition over HDAC3 and HDAC8[1][2].
| Catalog Number | I043931 |
| CAS Number | 1027971-34-1 |
| Synonyms | N-(4-phenoxyphenyl)-4-(3-phenylpropanoylamino)benzamide |
| Molecular Formula | C28H24N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C28H24N2O3/c31-27(20-11-21-7-3-1-4-8-21)29-23-14-12-22(13-15-23)28(32)30-24-16-18-26(19-17-24)33-25-9-5-2-6-10-25/h1-10,12-19H,11,20H2,(H,29,31)(H,30,32) |
| InChIKey | YPXLCXVERGDWHW-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCC(=O)NC2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)OC4=CC=CC=C4 |
| Reference | [1]. Hu E, et al. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J Pharmacol Exp Ther. 2003;307(2):720-728. [2]. Bieliauskas AV, Pflum MK. Isoform-selective histone deacetylase inhibitors. Chem Soc Rev. 2008;37(7):1402-1413. |
