For research use only. Not for therapeutic Use.
SB-431542 (CAT: I003052) is a selective inhibitor of the transforming growth factor-beta (TGF-β) type I receptor, also known as the activin receptor-like kinase (ALK) 5. It is widely used in biological and pharmaceutical research to study the TGF-β signaling pathway and its role in various cellular processes. SB-431542 specifically blocks the kinase activity of ALK5, preventing the phosphorylation of downstream signaling molecules and inhibiting TGF-β signaling. This compound has been employed to investigate the involvement of TGF-β signaling in processes such as cell differentiation, development, fibrosis, and cancer progression. SB-431542’s targeted inhibition of ALK5 makes it a valuable tool for understanding TGF-β signaling and exploring potential therapeutic applications.
Catalog Number | I003052 |
CAS Number | 301836-41-9 |
Synonyms | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide |
Molecular Formula | C22H16N4O3 |
Purity | ≥95% |
Target | TGF-βR1(ALK5) |
Solubility | DMSO: ≥ 40 mg/mL |
Storage | -20 ℃ |
IC50 | 94 nM (ALK5), 94 nM (Smad3) |
IUPAC Name | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide |
InChI | InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) |
InChIKey | FHYUGAJXYORMHI-UHFFFAOYSA-N |
SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |