For research use only. Not for therapeutic Use.
Selective 5-HT6 antagonist; a potential agent added to stabilize donepezil (Axon 1438) treatment in subjects with mild-to-moderate Alzheimer’s disease.
KEYWORDS: SB 742457 hydrochloride | supplier | 5-HT6 antagonist | GSK 742457 HCl | Intepirdine HCl | SB-742457 | GSK-742457 | CAS [607742-55-2] | [607742-69-8] | Serotonin | 5-HT6 | CNS | donepezil | Alzheimer’s disease | AD | GPCR
| Catalog Number | I047538 |
| CAS Number | 607742-55-2 |
| Molecular Formula | C19H19N3O2S.HCl |
| Purity | ≥95% |
| IUPAC Name | 3-(benzenesulfonyl)-8-piperazin-1-ylquinoline;hydrochloride |
| InChI | InChI=1S/C19H19N3O2S.ClH/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22;/h1-8,13-14,20H,9-12H2;1H |
| SMILES | C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4.Cl |
| Reference | N Idris et al. Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. Psychopharmacology 2010, 208 (1), 23–36.
G Maher-Edwards et al. Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer’s Disease. Curr. Alzheimer Res. 2009, 7(5), 374-385.
G Rossé G and H Schaffhauser. 5-HT(6) Receptor Antagonists as Potential Therapeutics for Cognitive Impairment. Curr. Top. Med. Chem. 2010, 10(2), 207-221.
N Upton et al. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease. Neurotherapeutics 2008, 5(3), 458–469.
Mitchell E.S. et al. 5-HT6 receptors: a novel target for cognitive enhancement. Pharmacol Ther. 2005, 108(3), 320-333. |
