SB-743921

• CAT Number: I005592
• CAS Number: 940929-33-9
• Molecular Formula: C31H33ClN2O3 • HCl
• Molecular Weight: 553.51
• Purity: ≥95%
• Synonyms: SB743921;SB 743921
• Target: Cytoskeleton
• Solubility: DMSO ≥110mg/mL Water ≥20mg/mL Ethanol ≥110mg/mL
• Storage: 3 years -20C powder
• IC50: 0.1 nM( Ki)
• IUPAC Name: N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide;hydrochloride
• InChI: InChI=1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1
• InChIKey: MLMZVWABFOLFGV-LNLSOMNWSA-N
• SMILES: CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

SB-743921(CAT: I005592) is a second-generation, highly potent inhibitor of kinesin spindle protein (KSP), also known as Eg5, widely utilized in oncology research. By targeting KSP, it disrupts mitotic spindle formation, leading to cell cycle arrest in the mitotic phase and subsequent apoptosis in rapidly dividing cancer cells. SB-743921 is particularly valuable for studying cancers with high mitotic activity, including hematological malignancies and solid tumors. Its improved potency and selectivity compared to earlier inhibitors make it a critical tool for preclinical studies aiming to develop targeted anticancer therapies that exploit mitotic spindle dynamics.