For research use only. Not for therapeutic Use.
Potent MSK inhibitor; In vitro, SB-747651A inhibits MSK1 with an IC50 value of 11 nM; In cells, SB-747651A fully inhibited MSK activity at 5-10 μM.SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells
| Catalog Number | I047576 |
| CAS Number | 2108968-31-4 |
| Molecular Formula | C16H22N8O.4HCl |
| Purity | ≥95% |
| IUPAC Name | 4-[1-ethyl-7-[(piperidin-4-ylamino)methyl]imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine;tetrahydrochloride |
| InChI | InChI=1S/C16H22N8O.4ClH/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13;;;;/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23);4*1H |
| SMILES | CCN1C2=C(C=NC=C2CNC3CCNCC3)N=C1C4=NON=C4N.Cl.Cl.Cl.Cl |
| Reference | S Naqvi et al. Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem J. 2012, 441(1), 347-357. |
