For research use only. Not for therapeutic Use.
SB1317(Cat No.:I000032), also known as Dihydrochloride, is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation. It inhibits CDK9 with an IC50 of 13 nM, leading to the suppression of RNA polymerase II-dependent transcription and the downregulation of various oncogenes. SB1317 has shown anticancer activity in preclinical studies, making it a promising candidate for the treatment of various malignancies, including hematological cancers and solid tumors.
Catalog Number | I000032 |
CAS Number | 937270-47-8 |
Synonyms | TG02; TG 02; TG02; SB1317; SB1317; SB 1317. |
Molecular Formula | C23H24N4O |
Purity | ≥95% |
Target | Protein Tyrosine Kinase/RTK |
Solubility | DMSO: ≤ 26.5 mg/mL |
Storage | Store at -20°C |
IC50 | 13/73/56 nM(CDK2/JAK2/FLT3) |
IUPAC Name | (16E)-14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene |
InChI | InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)/b3-2+ |
InChIKey | VXBAJLGYBMTJCY-NSCUHMNNSA-N |
SMILES | CN1CC=CCCOC2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C1 |
Reference | <br /> |