For research use only. Not for therapeutic Use.
SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1, Figure 1.
SBC-110736 (male C57BL/6 mice) lowers cholesterol levels in mice that were fed high fat diet, showing a mean of 38% reduction in total cholesterol levels after two weeks relative to high fat diet animal levels and a mean 50% reduction toward return to regular diet cholesterol levels[1].
| Catalog Number | I012008 |
| CAS Number | 1629166-02-4 |
| Synonyms | N-[4-[4-(4-methylphenyl)-2-phenylpiperazine-1-carbonyl]phenyl]acetamide |
| Molecular Formula | C26H27N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30) |
| InChIKey | PILMFSWQYWYOJC-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)N2CCN(C(C2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)NC(=O)C |
| Reference | [1]. Sherin Salaheldin Abdel-Meguid, et al. Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases. WO2014150395A1. |
