For research use only. Not for therapeutic Use.
SBI-183 is an orally active inhibitor of QSOX1 (Kd value of 20 μM), thereby suppressing the proliferative and invasive phenotype of two renal cancer cell lines (786-O and RCJ-41T2), a triple negative breast cancer (TNBC) cell line (MDA-MB-231), a lung adenocarcinoma cell line (A549), and a pancreatic ductal adenocarcinoma (MIA PaCa2). Moreover, SBI-183 inhibits tumor growth in two independent human xenograft mouse models of renal cell carcinoma.
KEYWORDS: SBI-183 | Supplier | QSOX1 inhibitor | SBI183 | SBI 183 | CAS [625403-59-0] | Non Selective (Thiols) | Thiol | Inhibitor | Enzymes
| Catalog Number | I047653 |
| CAS Number | 625403-59-0 |
| Molecular Formula | C18H20N2O2 |
| Purity | ≥95% |
| IUPAC Name | 3-methoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide |
| InChI | InChI=1S/C18H20N2O2/c1-22-17-6-4-5-14(13-17)18(21)19-15-7-9-16(10-8-15)20-11-2-3-12-20/h4-10,13H,2-3,11-12H2,1H3,(H,19,21) |
| SMILES | COC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)N3CCCC3 |
| Reference | AL Fifield et al. Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo. Mol Cancer Ther. 2020 Jan;19(1):112-122. |
