SBP-7455

• CAT Number: I036065
• CAS Number: 1884222-74-5
• Molecular Formula: C16H17F3N4O2
• Molecular Weight: 354.33
• Purity: 98%
• Synonyms: SBP-7455; SBP7455; SBP 7455
• Target: ULK
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: -20°C
• IUPAC Name: N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
• InChI: InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
• InChIKey: BQROJYIEHOOQBY-UHFFFAOYSA-N
• SMILES: COC1=C(OC)C=CC(NC2=NC(NC3CC3)=C(C(F)(F)F)C=N2)=C1

SBP-7455（Cat No.:I036065） is a dual inhibitor of ULK1 and ULK2 (ULK1/2), exhibiting enhanced binding affinity compared to SBI-0206965. It effectively inhibits the enzymatic activity of ULK1/2 both in vitro and in cells. SBP-7455 demonstrates potent reduction of viability in triple-negative breast cancer (TNBC) cells and displays oral bioavailability in mice. Moreover, it effectively suppresses starvation-induced autophagic flux in TNBC cells. These findings suggest that SBP-7455 holds potential as a therapeutic agent for TNBC by targeting the ULK1/2 pathway and regulating autophagy.