For research use only. Not for therapeutic Use.
SC-19220 is a competitive prostaglandinn E2 receptor antagonist. SC-19220 increases the bladder capacity and reduced the voiding efficiency of micturition (elicited by slow transvesical filling) of urethane-anesthetized rats. SC-19220 can restores the balance in bone marrow granulocyte and monocyte production after burn sepsis[1][2].
| Catalog Number | I009366 |
| CAS Number | 19395-87-0 |
| Synonyms | N’-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide |
| Molecular Formula | C16H14ClN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22) |
| InChIKey | KNURFLJTOUGOOQ-UHFFFAOYSA-N |
| SMILES | CC(=O)NNC(=O)N1CC2=CC=CC=C2OC3=C1C=C(C=C3)Cl |
| Reference | [1]. Maggi CA, et al. The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur J Pharmacol. 1988 Aug 2;152(3):273-9. [2]. Santangelo S, Shoup M, Gamelli RL, Shankar R. Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. J Trauma. 2000 May;48(5):826-30; discussion 830-1. |
