SC-558

• CAT Number: I012239
• CAS Number: 845674-84-2
• Molecular Formula: C16H11BrF3N3O2S
• Molecular Weight: 446.24
• Purity: ≥95%
• Synonyms: 4-[4-(4-Bromophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
• IUPAC Name: 4-[5-(4-bromophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
• InChI: InChI=1S/C16H11BrF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
• InChIKey: OYZKFVIVPRQRQQ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)Br

SC-558（Cat No.:I012239）is a selective inhibitor of cyclooxygenase-2 (COX-2), an enzyme involved in the production of prostaglandins that mediate inflammation and pain. It has been studied for its potential in treating inflammatory conditions, such as arthritis, and in reducing pain and swelling associated with these diseases. SC-558 is notable for its selectivity for COX-2 over COX-1, which may reduce gastrointestinal side effects typically seen with non-selective NSAIDs. Though its primary application is in pain management and inflammation, SC-558 also shows promise in cancer research due to COX-2’s involvement in tumorigenesis.