SC-58236

For research use only. Not for therapeutic Use.

  • CAT Number: R051798
  • CAS Number: 170569-86-5
  • Molecular Formula: C16H11ClF3N3O2S
  • Molecular Weight: 401.79
  • Purity: ≥95%
Inquiry Now

SC-236(Cat No.:R051798) is a potent, orally active COX-2-specific inhibitor (with an IC50 of 10 nM for COX-1) and a PPARγ agonist. It effectively inhibits activator protein-1 (AP-1) activity via c-Jun N-terminus and exerts anti-inflammatory effects by suppressing ERK phosphorylation in a mouse model. By selectively targeting COX-2 and modulating PPARγ, SC-236 holds potential as a therapeutic agent for various inflammatory conditions, offering a promising avenue for further research and development in the treatment of inflammatory disorders.


Catalog Number R051798
CAS Number 170569-86-5
Synonyms

4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; SC-58236; SC-236;

Molecular Formula C16H11ClF3N3O2S
Purity ≥95%
Target Vitamin D Related/Nuclear Receptor
Solubility Soluble in DMSO > 10 mM
Storage Store at 2-8°C
IUPAC Name 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
InChI InChI=1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
InChIKey NSQNZEUFHPTJME-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)Cl

Request a Quote