For research use only. Not for therapeutic Use.
SC-236(Cat No.:R051798) is a potent, orally active COX-2-specific inhibitor (with an IC50 of 10 nM for COX-1) and a PPARγ agonist. It effectively inhibits activator protein-1 (AP-1) activity via c-Jun N-terminus and exerts anti-inflammatory effects by suppressing ERK phosphorylation in a mouse model. By selectively targeting COX-2 and modulating PPARγ, SC-236 holds potential as a therapeutic agent for various inflammatory conditions, offering a promising avenue for further research and development in the treatment of inflammatory disorders.
Catalog Number | R051798 |
CAS Number | 170569-86-5 |
Synonyms | 4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; SC-58236; SC-236; |
Molecular Formula | C16H11ClF3N3O2S |
Purity | ≥95% |
Target | Vitamin D Related/Nuclear Receptor |
Solubility | Soluble in DMSO > 10 mM |
Storage | Store at 2-8°C |
IUPAC Name | 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide |
InChI | InChI=1S/C16H11ClF3N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25) |
InChIKey | NSQNZEUFHPTJME-UHFFFAOYSA-N |
SMILES | C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)Cl |