For research use only. Not for therapeutic Use.
SC-III3 is a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. SC-III3 reduces the viability of HepG2 cells and tumor growth of HepG2 xenograft mouse model. It induces the death of HepG2 cells by a way irrelevant to apoptosis and necrosis.
| Catalog Number | I009416 |
| CAS Number | 1660110-65-5 |
| Synonyms | SC-III3;(E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl) acrylamide |
| Molecular Formula | C19H14ClNO5 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| Reference | </br>1:SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. Zhao P, Dou Y, Chen L, Li L, Wei Z, Yu J, Wu X, Dai Y, Xia Y.Fitoterapia. 2015 Jul;104:31-40. doi: 10.1016/j.fitote.2015.05.002. Epub 2015 May 8. PMID: 25964188 </br>2:SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. Zhao P, Chen L, Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF, Dai Y.BMC Cancer. 2014 Dec 19;14:987. doi: 10.1186/1471-2407-14-987. PMID: 25527123 Free PMC Article |
