SC209 intermediate-1

• CAT Number: I040760
• CAS Number: 1977557-93-9
• Molecular Formula: C21H30N2O6
• Molecular Weight: 406.47
• Purity: ≥95%
• Synonyms: (2S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-3-[3-(prop-2-enoxycarbonylamino)phenyl]butanoic acid
• InChI: InChI=1S/C21H30N2O6/c1-8-12-28-18(26)22-15-11-9-10-14(13-15)21(5,6)16(17(24)25)23(7)19(27)29-20(2,3)4/h8-11,13,16H,1,12H2,2-7H3,(H,22,26)(H,24,25)/t16-/m1/s1
• InChIKey: WZSKLNHEJZJMLY-MRXNPFEDSA-N
• SMILES: CC(C)(C)OC(=O)N(C)C(C(=O)O)C(C)(C)C1=CC(=CC=C1)NC(=O)OCC=C

SC209 intermediate-1 (Compound A7a) is an ADC linker. SC209 intermediate-1 can be used for synthesis of ADCs[1].

Reference

[1]. Kline Toni, et al. Preparation of hemiasterlin derivatives and their antibody conjugates for use in cancer therapy. Patent. WO2016123582.