SC99

• CAT Number: I036098
• CAS Number: 882290-02-0
• Molecular Formula: C15H8Cl2FN3O
• Molecular Weight: 336.15
• Purity: 98%
• Synonyms: SC99; SC-99; SC 99
• Target: Stem Cell/Wnt
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
• IUPAC Name: 2-(2-(3-Chloro-4-fluorophenyl)hydrazono)-3-(4-chlorophenyl)-3-oxo-propanenitrile
• InChI: InChI=1S/C15H8Cl2FN3O/c16-10-3-1-9(2-4-10)15(22)14(8-19)21-20-11-5-6-13(18)12(17)7-11/h1-7,20H/b21-14+
• InChIKey: ZKULFSMYRSFHKE-KGENOOAVSA-N
• SMILES: N#C/C(C(C1=CC=C(Cl)C=C1)=O)=NNC2=CC=C(F)C(Cl)=C2

SC99（Cat No.:I036098） is a selective inhibitor of JAK2-STAT3 activation, a signaling pathway involved in cell proliferation and survival. By targeting this pathway, SC99 downregulates the expression of several genes modulated by STAT3, including Bcl-2, Bcl-xL, VEGF, cyclin D2, and E2F-1. This inhibition has potential therapeutic implications in various diseases characterized by dysregulated JAK2-STAT3 signaling, such as cancer.