For research use only. Not for therapeutic Use.
SCH-1473759（Cat No.:I000398）is a selective and potent inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase, a key regulator of angiogenesis. By inhibiting VEGFR-2, SCH-1473759 disrupts the formation of new blood vessels that supply nutrients and oxygen to tumors, effectively starving the cancer cells and inhibiting tumor growth. This compound is commonly used in oncology research to study its potential in anti-angiogenic cancer therapies. SCH-1473759’s specificity for VEGFR-2 makes it a promising candidate for investigating novel treatments for various cancers where angiogenesis plays a critical role.
| Catalog Number | I000398 |
| CAS Number | 1094069-99-4 |
| Synonyms | 2-[ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-ol |
| Molecular Formula | C20H26N8OS |
| Purity | ≥95% |
| Target | Aurora Kinase |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 4 nM (Aurora A); 13 nM (Aurora B) |
| IUPAC Name | 2-[ethyl-[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-1,2-thiazol-3-yl]methyl]amino]-2-methylpropan-1-ol |
| InChI | InChI=1S/C20H26N8OS/c1-5-27(20(3,4)12-29)11-15-6-17(30-26-15)25-18-19-21-9-16(14-7-22-23-8-14)28(19)10-13(2)24-18/h6-10,29H,5,11-12H2,1-4H3,(H,22,23)(H,24,25) |
| InChIKey | RHGZQGXELRMGES-UHFFFAOYSA-N |
| SMILES | CCN(CC1=NSC(=C1)NC2=NC(=CN3C2=NC=C3C4=CNN=C4)C)C(C)(C)CO |
| Reference | </br>1:A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma. Ferraz Nogueira Filho MA, Peer CJ, Nguyen J, McCalla A, Helman L, Figg WD.J Pharm Biomed Anal. 2017 Jan 5;132:223-226. doi: 10.1016/j.jpba.2016.10.003. Epub 2016 Oct 5. PMID: 27768921 </br>2:SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Basso AD, Liu M, Gray K, Tevar S, Lee S, Liang L, Ponery A, Smith EB, Monsma FJ Jr, Yu T, Zhang Y, Kerekes AD, Esposite S, Xiao Y, Tagat JR, Hicklin DJ, Kirschmeier P.Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33. doi: 10.1007/s00280-011-1568-1. Epub 2011 Feb 5. PMID: 21298383 |
