For research use only. Not for therapeutic Use.
SCH 29482（Cat No.:I009386）is a synthetic compound that functions as a potent and selective antagonist of the glycine receptor (GlyR). GlyRs are involved in inhibitory neurotransmission in the central nervous system. SCH 29482 has been studied for its potential in modulating neurological and psychiatric disorders, particularly those involving dysregulated glycinergic signaling. It has shown promise in preclinical studies for conditions like schizophrenia and spasticity. The compound’s pharmacological profile suggests that it could be a valuable tool in neuroscience research, although further clinical studies are needed to assess its therapeutic potential.
| Catalog Number | I009386 |
| CAS Number | 77646-83-4 |
| Synonyms | Sch 29482; Sch29482; Sch-29482.;4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(ethylthio)-6-((1R)-1-hydroxyethyl)-7-oxo-, (5R,6S)- |
| Molecular Formula | C10H13NO4S2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | Store at RT |
| IUPAC Name | (5R,6S)-3-ethylsulfanyl-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| InChI | InChI=1S/C10H13NO4S2/c1-3-16-10-6(9(14)15)11-7(13)5(4(2)12)8(11)17-10/h4-5,8,12H,3H2,1-2H3,(H,14,15)/t4-,5+,8-/m1/s1 |
| InChIKey | LDVDKTLZRGWFID-GLDDHUGJSA-N |
| SMILES | CCSC1=C(N2[C@H](S1)[C@H](C2=O)[C@@H](C)O)C(=O)O |
| Reference | </br>1:High-performance liquid chromatographic methods for the determination of the penems SCH 29482 and FCE 22101 in human serum and urine. Méndez R, Negro A, Martín-Villacorta J.J Chromatogr. 1992 Aug 7;579(1):115-21. PMID: 1447337 </br>2:Antimicrobial effects of the combination of ceftibuten and an orally absorbed penem SCH 29482. Chin NX, Gu JW, Neu HC.Diagn Microbiol Infect Dis. 1991 Jan-Feb;14(1):79-83. PMID: 2013213 </br>3:The activity of ceftazidime compared with those of aztreonam, newer cephalosporins and Sch 29482 against nonfermentative gram-negative bacilli. Schell RF, Francisco M, Bihl JA, LeFrock JL.Chemotherapy. 1985;31(3):181-90. PMID: 3888543 </br>4:Evaluation of Sch 29482 in experimental syphilis and comparison with penicillin G benzathine in disseminated disease and localized infection. Baughn RE, Adams C, Musher DM.Antimicrob Agents Chemother. 1984 Sep;26(3):401-4. PMID: 6508267 Free PMC Article</br>5:High-pressure liquid chromatographic method for determination of Sch 29482 in human serum. Kim H, Oden E, Lin C.Antimicrob Agents Chemother. 1982 Nov;22(5):848-51. PMID: 7181491 Free PMC Article</br>6:In-vitro activity of Sch 29482–a new penem antibiotic. Muench RL, Mayhew AL, Hindler JA, Hewitt WL, Young LS.J Antimicrob Chemother. 1982 Feb;9 Suppl C:71-8. No abstract available. PMID: 7061378 </br>7:Sch 29482, a new penem antibiotic: evaluation of in-vitro activity and effect of test conditions. Hare RS, Miller GH, Naples L, Sabatelli F, Loebenberg D, Waitz JA.J Antimicrob Chemother. 1982 Feb;9 Suppl C:7-16. No abstract available. PMID: 7061377 </br>8:Comparative in-vivo activity of Sch 29482 and six other extended spectrum cephalosporins. Weinstein RA, Nathan C, Kabins SA.J Antimicrob Chemother. 1982 Feb;9 Suppl C:41-8. No abstract available. PMID: 7061376 </br>9:Comparative in-vitro activity of Sch 29482, a new penem antibiotic. Reeves DS, Bywater MJ, Holt HA.J Antimicrob Chemother. 1982 Feb;9 Suppl C:31-40. No abstract available. PMID: 7061375 </br>10:Pharmacokinetics of Sch 29482 in rats. Lin C, Kim H, Chung M, Symchowicz S.J Antimicrob Chemother. 1982 Feb;9 Suppl C:233-7. No abstract available. PMID: 7061373 |
