For research use only. Not for therapeutic Use.
SCH-336 is a potent and selective CB2 inverse agonist. Sch.336 is an inverse agonist at hCB(2), as shown by its ability to decrease guanosine 5′-3-O-(thio)triphosphate (GTPgammaS) binding to membranes containing hCB(2), by the ability of GTPgammaS to left-shift Sch.336 binding to hCB(2) in these membranes, and by the compound’s ability to increase forskolin-stimulated cAMP levels in CHO cells expressing hCB(2).
| Catalog Number | I014675 |
| CAS Number | 447459-51-0 |
| Synonyms | SCH-336; SCH 336; SCH336.;N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide |
| Molecular Formula | C23H25NO8S3 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C23H25NO8S3/c1-16(24-33(4,25)26)17-5-10-20(11-6-17)34(27,28)22-14-9-19(32-3)15-23(22)35(29,30)21-12-7-18(31-2)8-13-21/h5-16,24H,1-4H3/t16-/m0/s1 |
| InChIKey | NXODIUKWAVUFGF-INIZCTEOSA-N |
| SMILES | CS(=O)(N[C@H](C1=CC=C(S(=O)(C2=CC=C(OC)C=C2S(=O)(C3=CC=C(OC)C=C3)=O)=O)C=C1)C)=O |
| Reference | </br>1: Lunn CA, Fine JS, Rojas-Triana A, Jackson JV, Fan X, Kung TT, Gonsiorek W,</br> Schwarz MA, Lavey B, Kozlowski JA, Narula SK, Lundell DJ, Hipkin RW, Bober LA. A </br> novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist</br> blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther. 2006</br> Feb;316(2):780-8. Epub 2005 Oct 28. PubMed PMID: 16258021.</br> </br> |
