SCH-336

• CAT Number: I014675
• CAS Number: 447459-51-0
• Molecular Formula: C23H25NO8S3
• Molecular Weight: 539.63
• Purity: ≥95%
• Synonyms: SCH-336; SCH 336; SCH336.;N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• IUPAC Name: N-[(1S)-1-[4-[4-methoxy-2-(4-methoxyphenyl)sulfonylphenyl]sulfonylphenyl]ethyl]methanesulfonamide
• InChI: InChI=1S/C23H25NO8S3/c1-16(24-33(4,25)26)17-5-10-20(11-6-17)34(27,28)22-14-9-19(32-3)15-23(22)35(29,30)21-12-7-18(31-2)8-13-21/h5-16,24H,1-4H3/t16-/m0/s1
• InChIKey: NXODIUKWAVUFGF-INIZCTEOSA-N
• SMILES: C[C@@H](C1=CC=C(C=C1)S(=O)(=O)C2=C(C=C(C=C2)OC)S(=O)(=O)C3=CC=C(C=C3)OC)NS(=O)(=O)C

SCH-336(CAT: I014675) is a highly potent and selective inverse agonist of the cannabinoid receptor 2 (CB2). By modulating CB2 signaling, it downregulates the receptor’s basal activity, providing a unique mechanism for exploring the role of CB2 in immune regulation and inflammation. SCH-336 is particularly valuable in research targeting inflammatory and autoimmune disorders, as well as in elucidating the distinct functions of CB2 in contrast to CB1 receptors. Its specificity and efficacy make it an essential tool in cannabinoid receptor pharmacology and the development of CB2-targeted therapeutic strategies.