For research use only. Not for therapeutic Use.
SCH-442416 (Cat No.: I009401) is a highly selective antagonist of the adenosine A2A receptor. It demonstrates strong binding affinity, with Ki values of 0.048 nM for human adenosine A2A receptors and 0.5 nM for rat adenosine A2A receptors. The specificity of SCH-442416 for A2A receptors makes it a valuable tool in pharmacological and neurological research, particularly in the study of adenosine receptor-related functions and potential therapeutic applications. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I009401 |
| CAS Number | 316173-57-6 |
| Synonyms | SCH-442416; SCH 442416; SCH442416.;2-(furan-2-yl)-7-(3-(4-methoxyphenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
| Molecular Formula | C20H19N7O2 |
| Purity | ≥95% |
| Target | Adenosine Receptor |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 4-(furan-2-yl)-10-[3-(4-methoxyphenyl)propyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine |
| InChI | InChI=1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24) |
| InChIKey | AEULVFLPCJOBCE-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)CCCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5 |
| Reference | </br>1:The effect of A 2A receptor antagonist (SCH 442416) on the mRNA expression of Kir 2.1 and Kir 4.1 channels in rat retinal Müller cells under hypoxic conditions in vitro. Kang X, Yu J, Wei Y, Zhao P.Adv Clin Exp Med. 2013 Nov-Dec;22(6):825-9. PMID: 24431311 Free Article</br>2:Effect of A(2A) receptor antagonist (SCH 442416) on the mRNA expression of glutamate aspartate transporter and glutamine synthetase in rat retinal Müller cells under hypoxic conditions in vitro. Yu J, Huang X, Wu Q, Wang J, Yu X, Zhao P.Exp Ther Med. 2012 May;3(5):803-806. Epub 2012 Feb 13. PMID: 22969972 Free PMC Article</br>3:In vitro effect of adenosine A2A receptor antagonist SCH 442416 on the expression of glutamine synthetase and glutamate aspartate transporter in rat retinal Müller cells at elevated hydrostatic pressure. Yu J, Zhong Y, Shen X, Cheng Y, Qi J, Wang J.Oncol Rep. 2012 Mar;27(3):748-52. doi: 10.3892/or.2011.1565. Epub 2011 Nov 29. PMID: 22134673 |
