For research use only. Not for therapeutic Use.
SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].
| Catalog Number | I009406 |
| CAS Number | 733717-87-8 |
| Synonyms | 2-[(2S)-5,5-dimethylmorpholin-2-yl]acetic acid |
| Molecular Formula | C8H15NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H15NO3/c1-8(2)5-12-6(4-9-8)3-7(10)11/h6,9H,3-5H2,1-2H3,(H,10,11)/t6-/m0/s1 |
| InChIKey | SEYCKMQSPUVYEF-LURJTMIESA-N |
| SMILES | CC1(COC(CN1)CC(=O)O)C |
| Reference | [1]. Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362(1):35-41. |
