SCH 58261

• CAT Number: I002036
• CAS Number: 160098-96-4
• Molecular Formula: C18H15N7O
• Molecular Weight: 345.41
• Purity: ≥95%
• Synonyms: 2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
• Target: Adenosine Receptor
• Solubility: Soluble to 100 mM in DMSO
• Storage: Store at RT
• IUPAC Name: 4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
• InChI: InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
• InChIKey: UTLPKQYUXOEJIL-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5

SCH 58261(CAT: I002036) is a potent and selective adenosine A2A receptor antagonist that acts competitively to block the activation of the A2A receptor, a G protein-coupled receptor involved in regulating neurotransmission, inflammation, and immune responses. By inhibiting A2A receptor signaling, SCH 58261 modulates dopaminergic activity in the brain, making it a valuable compound in neurodegenerative disease research, particularly for Parkinson’s disease and Huntington’s disease. Additionally, its anti-inflammatory properties make it relevant in studying cancer immunotherapy and inflammatory disorders. SCH 58261 is widely used to explore therapeutic strategies targeting adenosine-mediated pathways.