For research use only. Not for therapeutic Use.
SCH-79797（Cat No.:I009411）is a dual-action compound that functions as both a small-molecule protease-activated receptor-1 (PAR1) antagonist and a selective serotonin reuptake inhibitor (SSRI). It has been studied for its potential in treating cardiovascular diseases, particularly in preventing thrombosis by inhibiting PAR1, which plays a key role in platelet aggregation. SCH-79797 also exhibits antidepressant properties through its SSRI activity, making it a unique compound with potential applications in managing both cardiovascular and mood disorders. Its dual mechanism offers a promising therapeutic approach in clinical research.
| Catalog Number | I009411 |
| CAS Number | 245520-69-8 |
| Synonyms | SCH-79797; SCH 79797; SCH79797.;N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine |
| Molecular Formula | C23H27Cl2N5 |
| Purity | ≥95% |
| Target | PAR1 antagonist |
| Solubility | Soluble in DMSO |
| Storage | Desiccate at -20C |
| IUPAC Name | 3-N-cyclopropyl-7-[(4-propan-2-ylphenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine |
| InChI | InChI=1S/C23H25N5/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27) |
| InChIKey | AVXQPEKZIGPIJW-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=C(C=C1)CN2C=CC3=C2C=CC4=C3C(=NC(=N4)NC5CC5)N |
| Reference | </br>1:SCH 79797, a selective PAR1 antagonist, protects against ischemia/reperfusion-induced arrhythmias in the rat hearts. Mohamed OY, Al-Masri AA, El Eter EA, Lateef R.Eur Rev Med Pharmacol Sci. 2016 Nov;20(22):4796-4800. PMID: 27906419 Free Article</br>2:SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE.Basic Res Cardiol. 2007 Jul;102(4):350-8. Epub 2007 Apr 30. PMID: 17468933 Free PMC Article</br>3:Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Ahn HS, Foster C, Boykow G, Stamford A, Manna M, Graziano M.Biochem Pharmacol. 2000 Nov 15;60(10):1425-34. PMID: 11020444 |
