For research use only. Not for therapeutic Use.
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera[1]. Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia[2].
| Catalog Number | I017085 |
| CAS Number | 98619-25-1 |
| Synonyms | (2S,3S,4R)-4-(3,4-dimethoxyphenyl)-7-hydroxy-6-methoxy-2,3-dimethyl-3,4-dihydro-2H-naphthalen-1-one |
| Molecular Formula | C21H24O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H24O5/c1-11-12(2)21(23)15-9-16(22)18(25-4)10-14(15)20(11)13-6-7-17(24-3)19(8-13)26-5/h6-12,20,22H,1-5H3/t11-,12+,20-/m1/s1 |
| InChIKey | DRKPZVVNEGETTG-XAAFQQQXSA-N |
| SMILES | CC1C(C(=O)C2=CC(=C(C=C2C1C3=CC(=C(C=C3)OC)OC)OC)O)C |
| Reference | [1]. Lian-niang, L., et al. Schisandrone, a New 4-Aryltetralone Lignan fromSchisandra sphenanthera. Planta Medica, 1985, 51(03), 217–219. [2]. Qi Y, et al. An inhibitory effect of schisandrone on 伪-hemolysin expression to combat methicillin-resistant staphylococcus aureus infections. World J Microbiol Biotechnol. 2022 Nov 8;39(1):3. |
