For research use only. Not for therapeutic Use.
Sclerotiorin is a natural product isolated primarily from <em>Penicillium</em> species. It inhibits soybean lipoxygenase-<wbr></wbr>1 with an IC<sub>50</sub> value of 4.2 µM. Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC<sub>50</sub> = 19.4 µM),, inhibition of Grb2-<wbr></wbr>Shc interaction (IC<sub>50</sub> = 22 µM),, and antagonism of endothelin receptors (IC<sub>50</sub> = 114 and 152 µM for human ET<sub>A</sub> and ET<sub>B</sub>, respectively).
| Catalog Number | R067380 |
| CAS Number | 549-23-5 |
| Synonyms | 7-(acetyloxy)-5-chloro-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl-6H-2-benzopyran-6,8(7H)-dione |
| Molecular Formula | C₂₁H₂₃ClO₅ |
| Purity | ≥95% |
| Target | Anti-infection |
| Storage | -20°C |
| InChI | InChI=1S/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1 |
| InChIKey | SWJLTKXURNHVHE-UPWXJBBJSA-N |
| SMILES | CCC(C)C=C(C)C=CC1=CC2=C(C(=O)C(C(=O)C2=CO1)(C)OC(=O)C)Cl |
| Reference | 1.Chidananda, C., and Sattur, A.P. Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans. Journal of Agricultural and Food Chemistry 55, 2879-2883 (2007). |
